Use of warfarin during pregnancy.

Pregnancy Outcome with Intracytoplasmic Sperm Injection Method in a Woman with Prosthetic Heart Valves

There is an increased risk of thromboembolism, anticoagulant-related hemorrhage, fetal-wastage and congestive cardiac failure in pregnant women with mechanical heart valves. In order to have a good outcome, the care of such patients must necessarily be multidisciplinary and in a well- equipped centre with adequate support services .One such patient who had mechanical mitral and aortic valves re...

Anti-Coagulation During Pregnancy in Women with Mechanical Heart Valves: A Prospective Study

The search for a safe and effective anticoagulation regimen in pregnant women with mechanical prosthetic heart valves.

Warfarin, a time-honored treatment for nonpregnant patients with MPHV has been also shown to be effective in the prevention of thromboembolic complications during pregnancy (1–3). Exposure to warfarin in the first 6 to 12 weeks of pregnancy, however, can be associated with a significant risk to the fetus, including spontaneous abortions and warfarin embryopathy (1,3). In addition, the use of or...

Fetal and neonatal effects of anticoagulants used in pregnancy: a review.

There are several relative (promising regarding a reduction in placenta-mediated complications such as preeclampsia) and absolute (e.g. a recurrent or recent thromboembolic event, mechanical heart valves) reasons for use of anticoagulant drugs during pregnancy. Warfarin readily crosses the placenta because of its low molecular weight, and is associated with a distinctive embryopathy known as fe...

Anti-Coagulation During Pregnancy in Women with Mechanical Heart Valves: A Prospective Study

BACKGROUND Pregnancy is associated with a hypercoagulable state, therefore the optimal anticoagulants for potential use in pregnant women with prosthetic heart valves are controversial. The aim of this study is to investigate the effect of anticoagulants on pregnancy outcomes and their potential risks in pregnant women with mechanical heart valves. MATERIALS AND METHODS In this prospective co...